Report adds new data to existing
pool of U.S. and European research
“MoodPlus will give you your punch again.” Life wasn’t always as
promising for Debbie Bonick. Her moods were sometimes quite low
and other things she tried felt like they were clouding her mind. Then she
found out about SAM-e, a nonprescription dietary supplement sold under
the name Nature Made MoodPlus.
“MoodPlus only took a week* for me. I was just really surprised that it
worked as quickly as it did. It was like the world opened up to me.”
Debbie isn’t the only one who has discovered the benefits of Nature Made
MoodPlus SAM-e. In a report recently released by the U.S. Department of
Health and Human Services, SAM-e (pronounced “Sammy”) was found to
be an effective mood enhancer. 1
For more information about Nature
Made MoodPlus, call 1-800-276-2878
or visit www.NatureMade.com.
“This is a very important report because it has been commissioned by
the U.S. government,” says researcher and neuropharmacologist Teodoro
Bottiglieri of Baylor University’s Institute for Metabolic Diseases and
co-author of Stop Depression Now. “This report has not been
commissioned by an individual company or pharmaceutical interest.
It’s totally unbiased.”
To enhance mood, doctors recommend taking a SAM-e supplement such
as Nature Made MoodPlus, which is the same pharmaceutical-grade SAM-e
available and administered for more than 20 years by doctors in Europe.
“We all go through life with fluctuations in mood,” says Michael Jacobs,
M.D. Nature Made Mood Plus SAM-e offers the benefits of a safe and
effective means to enhance one’s sense of well-being.” Patients describe
a calmness or peacefulness when using MoodPlus, says Dr. Jacobs.
Why should I take MoodPlus?
Nature Made MoodPlus SAM-e supplement has three
What is MoodPlus?
SAM-e is a natural substance that exists throughout the body—it’s not
a prescription drug or herb. However, the body’s level of SAM-e can be
depleted because of poor diet and other health conditions. People
who are feeling especially blue have been found to have lower levels
of SAM-e. 2
• Works fast. In clinical studies, some people reported their mood
improved in as little as one week, although results may vary. 3– 5
• Few side effects. Side effects of SAM-e are comparable to those of a
placebo. Some other options are reported to be associated with damage
to the digestive tract, weight gain, and sexual dysfunction. 2– 6
• No known drug interactions. Numerous scientific studies of SAM-e
have not indicated interaction with drugs or other supplements.
The proven effectiveness and safety of SAM-e are why it has been
popular in Europe for decades and why it has been such a successful
product in the U.S. since 1999.
For more facts on SAM-e and to see the AHRQ report,
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
1 Agency for Healthcare Research & Quality. S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease. Available at: http://www.ahrq.gov/clinic/spcsums/samesum.htm. Accessed January 19,2004. The agency
stated that further research would be beneficial. They do not endorse any particular brand. 2 Bell KM, et al. Acta Neurol Scand. 1994; 154: 15-17. 3 Brown RP, et al. Clin Prac Alt Med. 2000; 1:230-241. 4 Brown R, et al. Psychiat Ann.
2002;32: 29-44. 5 Six Clinical Trials-all with oral administration (Kagan, 1990; Fava, 1992; Salmaggi, 1993; Cerutti, 1993; DeVanna, 1992; Pancheri, 2002). 6 Am J Med. 1987; 83(5A). (Caruso et al, pp. 66-71; Maccagno et al, pp. 72-77;
Vetter, pp. 78-80; Muller-Fassbender, pp. 81-83; Berger et al. pp 84-88; Konig, pp. 89-94).