Costco Connection - January 2008

Improves Mood Naturally

Supplement effectively enhances
mood, says a U.S. government report.
Report adds new data to existing pool
of U.S. and European research.

“MoodPlus will give you your punch again.” Life wasn’t always promising for Debbie Bonick. Her moods were sometimes quite low, and other things she tried felt like they were clouding her mind. Then she found out about SAM-e, a nonprescription dietary supplement sold under the name Nature Made MoodPlus.

“MoodPlus only took a week* for me. I was just really surprised that it worked as quickly as it did. It was like the world opened up to me.”

Debbie isn’t the only one who has discovered the benefits of Nature Made MoodPlus SAM-e. In a report recently released by the U.S. Department of Health and Human Services, SAM-e (pronounced “Sammy”) was found to be an effective mood enhancer. ¹

“This is a very important report because it has been commissioned by the U.S. government,” said researcher and neuropharmacologist Teodoro Bottiglieri of Baylor University’s Institute for Metabolic Diseases, co-author of Stop Depression Now. “This report has not been commissioned by an individual company or pharmaceutical interest. It’s totally unbiased.”

For more information about Nature Made MoodPlus, call 1-800-276-2878 or visit www.NatureMade.com.

To enhance mood, doctors recommend taking a SAM-e supplement such as Nature Made MoodPlus, which is the same pharmaceutical grade SAM-e available and administered for over 20 years by doctors in Europe.

“We all go through life with fluctuations in mood,” said Michael Jacobs, MD. “Nature Made Mood Plus SAM-e offers the benefits of a safe and effective means to enhance one’s sense of well-being.” Patients describe a calmness or peacefulness when using MoodPlus, said Dr. Jacobs.

Why should I take MoodPlus SAM-e?

Nature Made MoodPlus SAM-e supplement has three clear advantages:

What is MoodPlus SAM-e?

• Works fast: In clinical studies, some people reported their mood improved in as little as one week, although results may vary. ³^{– 5}

• Few side effects: Side effects of SAM-e are comparable to those of a placebo. Some other options are reported to be associated with damage to the digestive tract, weight gain and sexual dysfunction. ²^{– 6}

• No known drug interactions—Numerous scientific studies of SAM-e have not indicated interaction with drugs or other supplements. The proven effectiveness and safety of SAM-e are why it has been popular in Europe for decades and why it has been such a successful product in the United States since 1999.

SAM-e is a natural substance that exists throughout the body—it’s not a prescription drug or herb. However, the body’s level of SAM-e can be depleted because of poor diet and other health conditions. People who are feeling especially blue have been found to have lower levels of SAM-e. ²

For more facts on SAM-e and to see the AHRQ report, visit www.sam-e.com.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

11 Agency for Healthcare Research and Quality. S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease. Available at http://www.ahrq.gov/clinic/spcsums/samesum.htm. Accessed January 19,2004. The agency stated that further research would be beneficial. They do not endorse any particular brand. 2 Bell KM, et al. Acta Neurol Scand. 1994; 154: 15– 17. 3 Brown RP, et al. Clin Prac Alt Med. 2000; 1:230–241. 4 Brown R, et al. Psychiat Ann. 2002;32: 29– 44. 5 Six Clinical Trials-all with oral administration (Kagan, 1990; Fava, 1992; Salmaggi, 1993; Cerutti, 1993; DeVanna, 1992; Pancheri, 2002). 6 Am J Med. 1987; 83(5A). (Caruso et al, pp. 66-71; Maccagno et al, pp. 72– 77; Vetter, pp. 78– 80; Muller-Fassbender, pp. 81– 83; Berger et al. pp 84– 88; Konig, pp. 89– 94).